abstract：OBJECTIVE:Psychotic disorders in childhood and early adolescence often progress to chronic schizophrenia, but in many cases there are diagnosable medical and genetic causes or risk factors. We reviewed our clinical experience and the relevant literature to identify these factors and to define their clinical features, a...

journal_title：Schizophrenia research

authors： Giannitelli M,Consoli A,Raffin M,Jardri R,Levinson DF,Cohen D,Laurent-Levinson C

更新日期：2018-02-01 00:00:00

abstract：:Schizophrenia and at-risk populations are suggested to exhibit referential cohesion deficits in language production (e.g., producing fewer pronouns or nouns that clearly link to concepts from previous sentences). Much of this work has focused on transcribed speech samples, while no work to our knowledge has examined r...

journal_title：Schizophrenia research

authors： Gupta T,Hespos SJ,Horton WS,Mittal VA

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Previous literature suggests that better cognitive ability and insight are associated with greater lifetime risk of suicide attempts in schizophrenia, counter to the direction of association in the general population. However, the conjoint association between distinct cognitive domains, insight, and suicidal...

journal_title：Schizophrenia research

authors： Villa J,Choi J,Kangas JL,Kaufmann CN,Harvey PD,Depp CA

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The P300 event-related potential (ERP) component, which reflects cognitive processing, is a candidate biomarker for schizophrenia. However, the role of P300 in the pathophysiology of schizophrenia remains unclear because averaged P300 amplitudes reflect both genetic predisposition and current clinical status...

journal_title：Schizophrenia research

authors： Kim M,Lee TH,Kim JH,Hong H,Lee TY,Lee Y,Salisbury DF,Kwon JS

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). METHOD:A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more...

journal_title：Schizophrenia research

authors： Li Y,Li WX,Xie DJ,Wang Y,Cheung EFC,Chan RCK

更新日期：2018-02-01 00:00:00

abstract：:Research suggests that social stress exposure influences illness presentation and course among youth at clinical high-risk (CHR) for psychosis, though less is known about the extent to which self-reported perceptions of social stress relate to the severity of positive symptoms. Importantly, despite the notion that you...

journal_title：Schizophrenia research

authors： Millman ZB,Pitts SC,Thompson E,Kline ER,Demro C,Weintraub MJ,DeVylder JE,Mittal VA,Reeves GM,Schiffman J

更新日期：2018-02-01 00:00:00

abstract：:Unemployment rates for schizophrenia are high across all age groups compared to the general population. Past studies have focused on neurocognition as a key determinant of unemployment and poor work outcome in schizophrenia. However, several recent studies suggest that clinical symptoms may be equally or more importan...

journal_title：Schizophrenia research

authors： Llerena K,Reddy LF,Kern RS

更新日期：2018-02-01 00:00:00

abstract：:The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences...

journal_title：Schizophrenia research

authors： Schwarz E,Maukonen J,Hyytiäinen T,Kieseppä T,Orešič M,Sabunciyan S,Mantere O,Saarela M,Yolken R,Suvisaari J

更新日期：2018-02-01 00:00:00

abstract：:Biomarkers which predict response to atypical antipsychotic drugs (AAPDs) increases their benefit/risk ratio. We sought to identify common variants in genes which predict response to lurasidone, an AAPD, by associating genome-wide association study (GWAS) data and changes (Δ) in Positive And Negative Syndrome Scale (P...

journal_title：Schizophrenia research

authors： Li J,Yoshikawa A,Brennan MD,Ramsey TL,Meltzer HY

更新日期：2018-02-01 00:00:00

abstract：:Evidence from event-related-potential (ERP) studies has repeatedly shown differences in the perception and processing of auditory stimuli in children with dyslexia compared to control children. The mismatch negativity (MMN) - an ERP component reflecting passive auditory change detection ability - has been found to be ...

journal_title：Schizophrenia research

authors： Volkmer S,Schulte-Körne G

更新日期：2018-01-01 00:00:00

abstract：:Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively since the early 1990s, with the vast majority of studies using simple auditory oddball task deviants that vary in a single acoustic dimension such as pitch or duration. There has been a growing interest in using more complex devian...

journal_title：Schizophrenia research

authors： Avissar M,Xie S,Vail B,Lopez-Calderon J,Wang Y,Javitt DC

更新日期：2018-01-01 00:00:00

abstract：:The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre-treatment psychometric characteristics of the MCCB in a large ...

journal_title：Schizophrenia research

authors： Georgiades A,Davis VG,Atkins AS,Khan A,Walker TW,Loebel A,Haig G,Hilt DC,Dunayevich E,Umbricht D,Sand M,Keefe RSE

更新日期：2017-12-01 00:00:00

abstract：:Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased se...

journal_title：Schizophrenia research

authors： Lunsford-Avery JR,Dean DJ,Mittal VA

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Pharmaceutical companies conduct clinical trials to show the efficacy and safety of new medications for the treatment of schizophrenia. After the new medications are marketed, clinicians treating patients with schizophrenia discover that a considerable number of patients do not respond to these new medicatio...

journal_title：Schizophrenia research

authors： Aboraya A,Leucht S,Nasrallah HA,Samara M,Haro JM,Elshazly A,Zangeneh M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Current early screeners for psychosis-risk states have still to prove ability in identifying at-risk individuals. Among screeners, the 92-item Prodromal Questionnaire (PQ-92) is often used. We aimed to assess the validity of its Italian translation in a large Italian adolescent and young adult help-seeking s...

journal_title：Schizophrenia research

authors： Kotzalidis GD,Solfanelli A,Piacentino D,Savoja V,Fiori Nastro P,Curto M,Lindau JF,Masillo A,Brandizzi M,Fagioli F,Raballo A,Gebhardt E,Preti A,D'Alema M,Fucci MR,Miletto R,Andropoli D,Leccisi D,Girardi P,Loewy RL,

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to test the validity of the CHR state by focusing on the course of psychosis spectrum symptoms, depression and global functioning in converters and non-converters. A total of 188 CHR-positive subjects (60.2% men) aged between 13 and 35years (mean=20.5) at study outset were assessed five times...

journal_title：Schizophrenia research

authors： Hengartner MP,Heekeren K,Dvorsky D,Walitza S,Rössler W,Theodoridou A

更新日期：2017-11-01 00:00:00

abstract：:Schizophrenia has generally been viewed as having a unique preschizophrenia personality or destructive to the personality post-onset. This view is reflected in the scarcity of studies of personality in schizophrenia with the exception of schizotypal personality considered by many as an endophenotype of schizophrenia. ...

journal_title：Schizophrenia research

authors： Lewine R,Martin M,Hart M

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Working memory deficits represent a core feature of schizophrenia. These deficits have been associated with dysfunctional dorsolateral prefrontal cortex (DLPFC) cortical oscillations. Theta-gamma coupling describes the modulation of gamma oscillations by theta phasic activity that has been directly associate...

journal_title：Schizophrenia research

authors： Barr MS,Rajji TK,Zomorrodi R,Radhu N,George TP,Blumberger DM,Daskalakis ZJ

更新日期：2017-11-01 00:00:00

abstract：:Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of predictive meaningfulness and benefits of anti-inflammatory agents. According to a RCT in UHR-patients supplementation of omega-3 polyunsaturated fatty acids (PUFA) was effective in reduci...

journal_title：Schizophrenia research

authors： Smesny S,Milleit B,Schaefer MR,Hesse J,Schlögelhofer M,Langbein K,Hipler UC,Berger M,Cotter DR,Sauer H,McGorry PD,Amminger GP

更新日期：2017-10-01 00:00:00

abstract：:Cholesterol metabolism is vital for brain function. Previous work in cultured cells has shown that a number of psychotropic drugs inhibit the activity of 7-dehydrocholesterol reductase (DHCR7), an enzyme that catalyzes the final steps in cholesterol biosynthesis. This leads to the accumulation of 7-dehydrocholesterol ...

journal_title：Schizophrenia research

authors： Korade Ž,Liu W,Warren EB,Armstrong K,Porter NA,Konradi C

更新日期：2017-09-01 00:00:00

abstract：:The aim of this paper is to provide a brief review of mitochondrial structure as it relates to function and then present abnormalities in mitochondria in postmortem schizophrenia with a focus on ultrastructure. Function, morphology, fusion, fission, motility, ΔΨmem, ATP production, mitochondrial derived vesicles, and ...

journal_title：Schizophrenia research

authors： Roberts RC

更新日期：2017-09-01 00:00:00

abstract：:Schizophrenia is a heterogeneous spectrum disorder often associated with detrimental negative symptoms. In recent years, computational approaches to psychiatry have attracted growing attention. Negative symptoms have shown some overlap with general cognitive impairments and were also linked to impaired motivational pr...

journal_title：Schizophrenia research

authors： Deserno L,Heinz A,Schlagenhauf F

更新日期：2017-08-01 00:00:00

abstract：:The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CA...

journal_title：Schizophrenia research

authors： Blanchard JJ,Bradshaw KR,Garcia CP,Nasrallah HA,Harvey PD,Casey D,Csoboth CT,Hudson JI,Julian L,Lentz E,Nuechterlein KH,Perkins DO,Skale TG,Snowden LR,Tandon R,Tek C,Velligan D,Vinogradov S,O'Gorman C

更新日期：2017-07-01 00:00:00

abstract：:Clozapine is the only medication indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents, but its mechanism of action is poorly understood. To date, no studies of human postmortem brain have characterized the gene expression response to clozapine. Therefore, we addr...

journal_title：Schizophrenia research

authors： Lee BJ,Marchionni L,Andrews CE,Norris AL,Nucifora LG,Wu YC,Wright RA,Pevsner J,Ross CA,Margolis RL,Sawa A,Nucifora FC Jr

更新日期：2017-07-01 00:00:00

abstract：:Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning ...

journal_title：Schizophrenia research

authors： Browne J,Penn DL,Meyer-Kalos PS,Mueser KT,Estroff SE,Brunette MF,Correll CU,Robinson J,Rosenheck RA,Schooler N,Robinson DG,Addington J,Marcy P,Kane JM

更新日期：2017-07-01 00:00:00

abstract：:Patients with schizophrenia and bipolar disorder (BD) shared a significant overlap in genetic susceptibility, pharmacological treatment responses, neuropsychological deficits, and epidemiological features. However, it remains unknown whether these clinical overlaps are mediated by shared or disorder-specific abnormali...

journal_title：Schizophrenia research

authors： Dong D,Wang Y,Chang X,Jiang Y,Klugah-Brown B,Luo C,Yao D

更新日期：2017-07-01 00:00:00

abstract：:The watershed-hypothesis of schizophrenia asserts that over 200 different mutations dysregulate distinct pathways that converge on an unspecified common mechanism(s) that controls disease ontogeny. Consistent with this hypothesis, our RNA-sequencing of neuron committed cells (NCCs) differentiated from established iPSC...

journal_title：Schizophrenia research

authors： Narla ST,Lee YW,Benson CA,Sarder P,Brennand KJ,Stachowiak EK,Stachowiak MK

更新日期：2017-07-01 00:00:00

abstract：:Impaired fiber bundle connectivity between brain regions is a key neuropathological finding in schizophrenia. Symptom dimensions in schizophrenia can be clustered into factor models. Single syndromes have been related to grey and white matter brain structure alterations. We associated all core syndromes of schizophren...

journal_title：Schizophrenia research

authors： Bopp MHA,Zöllner R,Jansen A,Dietsche B,Krug A,Kircher TTJ

更新日期：2017-06-01 00:00:00

abstract：:Impaired insight is a hallmark feature of schizophrenia. Structural studies implicate predominantly prefrontal, cingulate, cuneus/precuneus, and inferior temporal brain regions. The cortical midline structures (CMS) are also implicated in functional studies primarily through self-reflective processing tasks. However, ...

journal_title：Schizophrenia research

authors： Asmal L,du Plessis S,Vink M,Fouche JP,Chiliza B,Emsley R

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) and schizophrenia are neurodevelopmental conditions that are characterized by significant social impairment. Emerging genomic and neurobiological evidence has increasingly pointed to shared pathophysiologic mechanisms in the two disorders. Overlap in social impairment may refle...

journal_title：Schizophrenia research

authors： Eack SM,Wojtalik JA,Keshavan MS,Minshew NJ

更新日期：2017-05-01 00:00:00

abstract：:Defeatist beliefs and amotivation are prominent obstacles in vocational rehabilitation for people with serious mental illnesses (SMI). The CBT-based Indianapolis Vocational Intervention Program (IVIP) was specifically designed to reduce defeatist beliefs related to work functioning. In the current study, we examined t...

journal_title：Schizophrenia research

authors： Mervis JE,Fiszdon JM,Lysaker PH,Nienow TM,Mathews L,Wardwell P,Petrik T,Thime W,Choi J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period ...

journal_title：Schizophrenia research

authors： Wils RS,Gotfredsen DR,Hjorthøj C,Austin SF,Albert N,Secher RG,Thorup AA,Mors O,Nordentoft M

更新日期：2017-04-01 00:00:00

abstract：:The purpose of the present study was to investigate the patterns of interregional correlations of serotonin transporter (SERT) availability with glucose metabolism using 7-Tesla magnetic resonance imaging (MRI) and high-resolution positron emission tomography (PET) with 11C-3-amino-4-(2-dimethylaminomethylphenylthio)b...

journal_title：Schizophrenia research

authors： Kim JH,Kim JH,Son YD,Joo YH,Lee SY,Kim HK,Woo MK

更新日期：2017-04-01 00:00:00

abstract：:Sleep disturbances have been reliably reported in patients with schizophrenia, thus suggesting that abnormal sleep may represent a core feature of this disorder. Traditional electroencephalographic studies investigating sleep architecture have found reduced deep non-rapid eye movement (NREM) sleep, or slow wave sleep ...

journal_title：Schizophrenia research

authors： Ferrarelli F,Tononi G

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Some studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance. AIMS:To conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin ...

journal_title：Schizophrenia research

authors： Greenhalgh AM,Gonzalez-Blanco L,Garcia-Rizo C,Fernandez-Egea E,Miller B,Arroyo MB,Kirkpatrick B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Aberrations in body perception are common in psychotic disorders. The insula and temporoparietal junction (TPJ) are involved in body ownership and spatial perception suggesting that abnormal structure of these regions might be related to the expression of perceptual aberrations in psychosis. METHODS:58 indi...

journal_title：Schizophrenia research

authors： Brosey EA,Woodward ND

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Individuals with schizophrenia tend to have low levels of physical activity (PA) which contributes to high rates of physical comorbidities. Valid and reliable methods of assessing PA are essential for advancing health research. Ten years after initial validation of the Short-Form International Physical Activ...

journal_title：Schizophrenia research

authors： Duncan MJ,Arbour-Nicitopoulos K,Subramanieapillai M,Remington G,Faulkner G

更新日期：2017-01-01 00:00:00

abstract：:Younger patients with schizophrenia have most likely experienced fewer adverse consequences of the illness than older patients who may have experienced a lifetime of treatment as well as socio-economic problems as a consequence of the illness. There is limited information regarding differential efficacy of long-acting...

journal_title：Schizophrenia research

authors： Targum SD,Risinger R,Du Y,Pendergrass JC,Jamal HH,Silverman BL

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To explore the impact of the introduction of newer antipsychotic long-acting injections (LAIs) on trends in LAI prescribing and characteristics associated with initiation of LAIs in naturalistic conditions. METHODS:The study was performed using reimbursement data from the French Insurance Healthcare system. ...

journal_title：Schizophrenia research

authors： Verdoux H,Pambrun E,Tournier M,Bezin J,Pariente A

更新日期：2016-12-01 00:00:00

abstract：:Viral infections during fetal and adolescent periods, as well as during the course of schizophrenia itself have been linked to the onset and/or relapse of a psychosis. We previously reported that the unique antipsychotic aripiprazole, a partial D2 agonist, inhibits the release of tumor necrosis factor (TNF)-α from int...

journal_title：Schizophrenia research

authors： Sato-Kasai M,Kato TA,Ohgidani M,Mizoguchi Y,Sagata N,Inamine S,Horikawa H,Hayakawa K,Shimokawa N,Kyuragi S,Seki Y,Monji A,Kanba S

更新日期：2016-12-01 00:00:00